Dark Donna Basic Naketano Giacca Blue FwfEftqzp

Advertisement

Dark Donna Basic Naketano Giacca Blue FwfEftqzp

  • Giuseppe Martini
  • Luigi Gennari
  • Ranuccio Nuti
  • Giuseppe Martini
    • 1
  • Luigi Gennari
    • 1
  • Ranuccio Nuti
    • 1
  1. 1.Dipartimento di Medicina Interna, Scienze Endocrinologiche e BiochimicheUniversità degli Studi di SienaSiena
Chapter

Riassunto

L’osteomalacia è un’osteopatia demineralizzante di natura metabolica caratterizzata dalla presenza di tessuto osteoide non calcificato in misura superiore alla norma. L’osteomalacia si realizza tipicamente nel soggetto adulto ed è espressione di un’alterazione dei meccanismi di mineralizzazione. Quando il difetto di calcificazione insorge nello scheletro in accrescimento, si usa il termine di rachitismo. Il difetto di mineralizzazione del rachitismo interessa, oltre che la matrice osteoide dell’osso, anche la matrice cartilaginea delle cartilagini di accrescimento, prima che si realizzi la loro fusione.

This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Giacche Donna Grazioso Lunghe College Relaxed Maniche Casual Outerwear Lacci Bomber Cappotto Eleganti Fashion Stlie Pilot Autunno Stampate Schwarz Con Giacca Fpq51wYx

Unable to display preview. Giacche Donna Grazioso Lunghe College Relaxed Maniche Casual Outerwear Lacci Bomber Cappotto Eleganti Fashion Stlie Pilot Autunno Stampate Schwarz Con Giacca Fpq51wYx

Bibliografia

  1. 1.
    Stanbury S.W, Mawer E.B () Metabolic disturbances in acquired osteomalacia. In: Cohen RD, Lewis B, Alberti K, Denman AM (eds) The metabolic and molecular basis of acquired disease. Bailliere Tindall, London, pp 1717–1782 Google Scholar
  2. 2.
    Parfitt AM (1992) Human bone mineralization studied by in vivo tetracycline labeling: Application to the pathophysiology of osteomalacia. Excerpta Medica International Congress, 4th International Symposium on Chemistry and Biology of Mineralized Tissues, Coronado Peninsula, California, pp 465–474 Google Scholar
  3. 3.
    Baylink D, Stauffer M, Wergedal J, Rich C (1970) Formation, mineralization and resorption of bone in vitamin Ddeficient rats. J Clin Invest 49:1122–1134 PubMedCrossRefGoogle Scholar
  4. 4.
    Parfitt AM, Rao DS, Stanciu J et al (1985) Irreversible bone loss in osteomalacia. Comparison of radial photon absortiometry with iliac bone histomorphometry during treatment. J Clin Invest 76:2403–2412 PubMedCrossRefGoogle Scholar
  5. 5.
    Meisen F, Mosekilde L (1980) Trabecular bone mineralization lag time determined by tetracycline double-labeling in normal and certain pathological conditions. APMIS 88:83–88 Basic Dark Giacca Blue Donna Naketano Google Scholar
  6. 6.
    Eriksen EF, Steiniche T, Mosekilde L, Meisen F (1989) Histomorphometric analysis of bone in metabolic bone disease. Endocrinol Metab Clin N Am 18:919–954 Google Scholar
  7. 7.
    Mustafa A, Bigras JL, McCrindle BW (1999) Dilated cardiomyopathy as a first sign of nutritional vitamin D deficiency rickets in infancy. Can J Cardiol 16:699–701 Google Scholar
  8. 8.
    Banajeh SM, al-Sunbali NN, al-Sanahani SH (1997) Clinical characteristics and outcome of children aged under 5 years hospitalized with severe pneumonia in Yemen. Ann Trop Paediatr 17:321–326 PubMedGoogle Scholar
  9. 9.
    Aaron J (1978) Histological aspects of the relationship between vitamin D and bone. In: Lawson DEM (ed) Vitamin D. Academic Press, London, pp 201–265 Google Scholar
  10. 10.
    Parfitt AM (1998) Osteomalacia and related disorders. In: Avioli LV, Krane SM (eds) Metabolic bone disease and clinically related disorders. Academic Press, London, pp 327–386 CrossRefAuk055 Giacche Outwear Moto In Black Pelle Uomo Slim Giacca Biker Cappotto Da Fit qAxwT4PFOn
  11. 11.
    Stamp TCB, Walker PP, Peiry W, Jenkins MV (1980) Nutritional osteomalacia and late rickets in greater London 1974–1979: clinical and metabolic studies in 45 patients. J Clin Endocrinol Metab 9:81–105 CrossRefGoogle Scholar
  12. 12.
    Parfitt AM, Duncan H (1982) Metabolic bone disease affecting the spine. In: Rothman R, Simeone F (eds): The Spine. WB Saunders Co, Philadelphia, pp 775–905 Blue Dark Basic Giacca Naketano Donna Google Scholar
  13. 13.
    Young A, Edwards RHT, Jones DA, Brenton DP (1981) Quadriceps, muscle strength and fibre size during the treatment of osteomalacia. In: Stokes IAF (ed) Mechanical factors and skeleton. John Libbey, London, pp 137–145 Google Scholar
  14. 14.
    Skaria J, Katiyar BC, Srivastava TP, Dube B (1975) Myopathy and neuropathy associated with osteomalacia. Acta Neurol Scand 51:37–58 PubMedGoogle Scholar
  15. 15.
  16. 16.
    McKenna MJ, Kleerekoper M, Ellis BI et al (1987) Atypical insufficiency fractures confused with Looser zones of osteomalacia. Bone 8:71–78 PubMedCrossRefGoogle Scholar
  17. 17.
    Parfitt AM (1972) Hypophosphatemic vitamin D refractory rickets and osteomalacia. Orthop Clin N Am 3:653–680 Google Scholar
  18. 18.
    Goldring SR, Krane SM (1989) Disorders of calcification: Osteomalacia and Rickets. In: DeGroot LJ, Jameson JL (eds) Endocrinology. WB Saunders Co, Philadelphia, pp 1223–1243 Google Scholar
  19. 19.
    Li F, Iqbal J, Wassif W et al (1994) Carboxyterminal propeptide of type 1 procollagen in osteomalacia. Calcif Tissue Int 55:90–93 PubMedCrossRefGoogle Scholar
  20. 20.
    Anderson J, Bannister DW, Parsons V, Tomlinson RWS (1967) Total urinary hydroxyproline excretion in osteomalacia. Calcif Tissue Res 1:183–191 PubMedCrossRefGoogle Scholar
  21. 21.
    Smith R, Dick M (1968) Total urinary hydroxyproline in osteomalacia and the effect upon it of treatment with vitamin D. Clin Sci 34:43–56 PubMedGoogle Scholar
  22. 22.
    Demiaux B, Arlot ME, Chapuy MC et al (1992) Serum osteocalcin is increased in patients with osteomalacia: Correlations with biochemical and histomorphometric findings. J Clin Endocrinon Metab 74:1146–1151 CrossRefGoogle Scholar
  23. 23.
    Luftner D, Bollow M, Sturzenbecher A et al (2001) Biomarkers and imaging in non-malignant and malignant osteomalacia. Int J Biol Markers 16:136–141 PubMedGoogle Scholar
  24. 24.
    Holick MF (1981) The cutaneous synthesis of previtamin D3: a unique photo-endocrine system. J Invest Dermatol 76:51–58 CrossRefGoogle Scholar
  25. 25.
    DeLuca HF (1984) The metabolism, physiology, and function of vitamin D. In: Kumar R (ed) Vitamin D, basic and clinical aspects. Nijhoff, Boston/The Hague, pp 1–68 Google Scholar
  26. 26.
    Matsumoto O, Ohyama Y, Okuda K (1988) Purification and characterization of vitamin D3 25-hydroxilase from rat liver. J Biol Chem 254:9518–9523 Marikoo Marikoo Donna Giacca Giacca Rot 4pd6pH
  27. Naketano Giacca Blue Dark Basic Donna 27.
    Henry HL (1979) Regulation of the hydroxylation of 25-hydroxyvitamin D3 in vivo and in primary cultures of chick kidney cells. J Biol Chem 254:2722–2727 PubMedGoogle Scholar
  28. 28.
    Reichel H, Koeffler HF, Norman AW (1989) The role of the vitamin D endocrine system in health and disease. N Engl J Med 15:980–991 CrossRefGoogle Scholar
  29. 29.
    Caniggia A, Nuti R, Galli M et al (1986) Effect of a longterm treatment with 1,25-dihydroxyvitamin D3 on osteocalcin in postmenopausal osteoporosis. Calcif Tissue Int 38:328–332 PubMedCrossRefGoogle Scholar
  30. Blue Donna Basic Giacca Dark Naketano 30.
    Peacock M (1998 ) Effects of calcium and vitamin D insufficiency on the skeleton. Osteoporos Int Suppl 8:S45–S51 Google Scholar
  31. 31.
    Malabanan A, Veronikis IE, Holick MR (1998) Redefining vitamin D insufficiency. Lancet 351:805–806 Giacca Basic Blue Donna Naketano Dark PubMedCrossRefGoogle Scholar
  32. 32.
    Sahota O, Masud T, San P, Hosking DJ (1999) Vitamin D insufficiency increases bone turnover markers and enhances bone loss at the hip in patients with established vertebral osteoporosis. Clin Endocrinol 51:217–221 Ufficio Lunga Eleganti Fit Schwarz Blazer Business Autunno Monocromo Fashion Giubbino Primaverile Casuale Battercake Manica Camicia Allentato Donne Slim Cappotto Donna Corto npZzqSfGoogle Scholar
  33. 33.
    Need AG, Morris HA, Horowitz M, Nordin BEC (1993) Effects of skin thickness, age, body fat and sunlight on serum 25-hydroxyvitamin D. Am J Clin Nutr 58:882–885 PubMedGoogle Scholar
  34. 34.
    Holick MF, Matsuoka LY, Wortsman J (1989) Age, vitamin D and solar irradiation. Lancet ii: 1104–1105 CrossRefGoogle Scholar
  35. 35.
    Heaney RP, Recker RR, Stegman MR, Moy AJ (1989) Calcium absorption in women. Relationships to calcium intake, estrogen status and age. J Bone Miner Res 4:460–475 Google Scholar
  36. 36.
    Dunnigan MG, Henderson JB (1997) An epidemiological model of privational rickets and osteomalacia. Proc Nutr Soc 56:939–956 PubMedCrossRefGoogle Scholar
  37. 37.
    Mawer EB, Davies M (1997) Bone disorders associated with gastrointestinal and hepatobiliar disease. Vitamin D. Academic Press, San Diego, pp 831–847 Google Scholar
  38. 38.
    Davies M, Mawer EB, Krawitt EL (1980) Comparative absorption of vitamin D3 and 25-hydroxyvitamin D3 in intestinal disease. Gut 21:287–292 PubMedCrossRefGoogle Scholar
    39. Leggera Sportiva Sirocco Giacca K way Impermeabile Antivento B amp;c Donna Viola Woman 8qzCvwCxn
  39. 39.
    Davies M, Heys SE, Selby PS. et al (1997) Increased catabolism of 25-hydroxyvitamin D in patients with partial gastrectomy and elevated 1,25-dihydroxyvitamin D levels. Implications for metabolic bone disease. J Clin Endocrinol Metab 82:209–212 PubMedCrossRefGoogle Scholar
  40. 40.
    Corazza GR, Di Sario A, Cecchetti L et al (1995) Bone mass and metabolism in patients with celiac disease. Gastroenterology 109:122–128 PubMedCrossRefGoogle Scholar
  41. 41.
    Nuti R, Martini G, Valenti R et al (2001) Prevalence of undiagnosed coeliac sindrome in osteoporotic women. J Intern Med 250:361–366 PubMedUfficio Lunga Eleganti Fit Schwarz Blazer Business Autunno Monocromo Fashion Giubbino Primaverile Casuale Battercake Manica Camicia Allentato Donne Slim Cappotto Donna Corto npZzqSfGoogle Scholar
  42. 42.
    Haworth CS, Selby PL, Webb AK et al (1999) Low bone mineral density in adults with cystic fibrosis. Thorax 54:961–967 PubMedBasic Scuro Verde Naketano Donna Giacca O8xURGoogle Scholar
  43. 43.
    Hahn TJ, Birge SJ, Scharp CR, Avioli LV (1972) Phenobarbital induced alterations in vitamin D metabolism. J Clin Invest 51:741–748 PubMedCrossRefGoogle Scholar
  44. 44.
    Clements MR, Davies M, Fraser DR et al (1987) Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism. Clin Sci 73:659–664 Denim Elastici Pantaloni Dei A Di Especial Estilo Uomo Dunkelblau Dell'anello Jeans Fit Sigaretta Slim Modo WWErnXGoogle Scholar
  45. 45.
    Krawitt EL, Grundman MJ, Mawer EB (1977) Absorption, hydroxylation and excretion of vitamin D3 in primary biliary cirrhosis. Lancet ii: 1246–1249 CrossRefGoogle Scholar
  46. 46.
    Mawer EB, Klass HJ, Warnes TW, Berry JL (1985) Metabolism of vitamin D in patients with primary biliary cirrhosis and alcoholic liver disease. Clin Sci 69:561–570 PubMedGoogle Scholar
  47. 47.
    Davies M, Mawer EB, Klass HJ et al (1983) Vitamin D deficiency, osteomalacia, and primary biliary chirrosis. Response to orally administered vitamin D. Dig Dis Sci 28:145–153 PubMedCrossRefGoogle Scholar
  48. 48.
    Goodman WG, Coburn JW, Slatoposky E et al (2003) Renal osteodistrophy in adults and children. In: Favus MJ (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism. American Society of Bone and Mineral Research, Washington DC, pp 430–447 Google Scholar
  49. 49.
    Miller WL, Portale AA (1999) Genetic causes of rickets. Curr Opin Pediatr 11:333–339 PubMedCrossRefGoogle Scholar
  50. 50.
    St-Arnaud R, Messerlian S, Moir JM et al (1997) The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus. J Bone Miner Res 12:1552–1559 Top Long Sleeve Pullover Print Women Blouse Sweatshirt Morwind White Casual 0ASpw1xHqCrossRefGoogle Scholar
  51. 51.
    Yoshida T, Monkawa T, Tenenhouse HS (1998) Two novel lalpha-hydroxylase mutations in French-Canadians with vitamin D dependency rickets type II. Kidney Int 54:1437–1443 PubMedUfficio Lunga Eleganti Fit Schwarz Blazer Business Autunno Monocromo Fashion Giubbino Primaverile Casuale Battercake Manica Camicia Allentato Donne Slim Cappotto Donna Corto npZzqSfGoogle Scholar
  52. 52.
    Smith SJ, Rucka AK, Berry JL, Daves M (1999) Novel mulations in the 1-alpha-hydroxylase (P450cl) gene in three families with pseudo-vitamin D-deficiency rickets resulting in loss of functional enzyme activity in blood-derived macrophages. J Bone Miner Res 15:730–739 CrossRefGoogle Scholar
  53. 53.
    Rowe PS (1998) The role of the PHEX gene (PEX) in families with X-linked hypoposphataemic rickets. Curr Opin Nephrol Hypertens 7:367–376 PubMedGoogle Scholar
  54. 54.
    Kilanaka S, Takeyama K, Murayama A et al (1998) Inactivating mutations in the 25-hydroxyvitamin D 1-alpha-hydroxylase gene in patients with pseudovitamin D-deficiency rickets. N Eng J Med 338:653–661 CrossRefGoogle Scholar
  55. 55.
    Glorieux FH, St-Arnaud R (1998) Molecular cloning of (25-OH D)-1 alpha-hydroxylase: an approach to the understanding of vitamin D pseudo-deficiency. Recent Prog Horm Res 53:341–349 PubMedGoogle Scholar
  56. 56.
    Wang JT, Lin CJ, Burridge SM et al (1998) Genetics of vitamin D 1-alpha-hydroxylase deficiency in 17 families. Am J Hum Genet 63:1694–1702 PubMedCrossRefGoogle Scholar
  57. 57.
    Takeda E, Vamamoto H, Taketani Y et al (1997) Vitamin D-dependent rickets type 1 and type II. Acta Paediatr Jpn 39:508–513 PubMedDonna Giacca Dunkelblau Camicia Ital design qUAHwFn
  58. 58.
    Haussler MR, Haussler CA, Jurutka PW et al (1997) The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol 154:S57–S573 PubMedCrossRefGoogle Scholar
  59. 59.
    Zhu W, Malloy PJ, Delvin E et al (1998) Hereditary 1,25-dihydroxyvitamin D resistant rickets due to an opal mutation causing premature termination of the vitamin D receptor. J Bone Miner Res 13:259–264 Donna Denim Jeans Woman Stretch Roger's Roy Blu Super Cut Cate Frick wnqxz7fp4WCrossRefGoogle Scholar
  60. 60.
    Dominguez JH, Gray RW, Lemann J (1976) Dietary phosphate deprivation in women and men. Effects on mineral and acid balance, parathyroid hormone and the metabolism of 25-OH-vitamin D. J Clin Endocrinol Metab 43:1056–1068 Jeans Xx Stonewash Blu corto 50 Aztec It Uomo 7SdqWPwRway grey Giubbotto Unisex K0064m0 K Multicolore black dqHYnZGoogle Scholar
  61. 61.
    Lotz M, Zisman E, Bartter FC (1968) Evidence for a phosphorus-depletion syndrome in man. N Engl J Med 278:409–452 PubMedCrossRefGoogle Scholar
  62. 62.
    Winters R, Graham J, Williams T et al (1958) A genetic study of familial hypophosphatemia and vitamin D resistant rickets with a review of the literature. Medicine 37:97–142 PubMedBasic Blue Naketano Donna Giacca Dark CrossRefGoogle Scholar
  63. 63.
    Davies M, Stanbury S (1981) The rheumatic manifestations of metabolic bone disease. Clinic Rheum Dis 7:595–646 Google Scholar
  64. 64.
    Econs M, Drezner M (1992) Bone disease resulting from inherited disorders o renal tubule transport and vitamin D metabolism. In: Favus M, Coe F (eds) Disorders of bone and mineral metabolism. Raven Press, New York, pp 935–950 Google Scholar
  65. 65.
    Tenenhouse H, Econs M (2001) Mendelian hypophosphatemias. In: Scriver CR, Beaudet AL, Sly WS et al (eds): The metabolic and molecular bases of inherited disease. McGraw-Hill, New York, pp 5313–5329 Google Scholar
  66. 66.
    Bradbury P, Brenton D, Stern G (1987) Neurological involvement in X-linked hypophosphatemic rickets. J Neurol Neurosurg Psichiatry 50:810–812 Basic Blue Giacca Dark Naketano Donna CrossRefGoogle Scholar
  67. 67.
    Coleman E, Foole J (1954) Craniostenosis with familial vitamin-D-resistant rickets. Brit Med J 1:561–562 Donna Naketano Giacca Blue Dark Basic PubMedCrossRefGoogle Scholar
  68. 68.
    HYP Consortium (1995) A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. Nat Genet 11:130–136 CrossRefGoogle Scholar
  69. 69.
    Francis F, Strom TM, Hennig S et al (1997) Genomic organization of the human PEX gene mutated in X-linked dominant hypophosphatemic rickets. Genome Res 7:573–585 PubMedDonna Giacca Dark Naketano Blue Basic Google Scholar
  70. 70.
    White K, Speer M, Biber J et al (1998) Refining the autosomal dominant hypophosphatemic rickets (ADHR) interval on chromosome 12p13 and localization of two candidate ADHR genes. Bone 23:S379 CrossRefGoogle Scholar
  71. 71.
    Tieder M, Modai D, Samuel R et al (1985) Hereditary hypophosphatemic rickets with hypercalciuria. N Engl J Med 312:611–617 Giacca Naketano Donna Basic Dark Blue PubMedCrossRefSirocco way Leggera Antivento Woman Rosso Giacca K amp;c B Donna Impermeabile Sportiva UYcfSqwGoogle Scholar
  72. 72.
    Nishiyama S, Inoue F, Matsuda I (1986) A single case of hypophosphatemic rickets with hypercalciuria. J Pediatr Gastroenterol Nutr 5:826 PubMedElegante Di Imbottita Pelliccia Invernali Giaccone Donna Giacca Lunga Monocromo Lanoso Moda Party Manica Khaki Giubotto Giovane Women Unico Cappotto Iq1nwGoogle Scholar
  73. 73.
    Tieder M, Arie R, Bab I et al (1992) A new kindred with hereditary hypophosphatemic rickets with hypercalciuria. Implications for correct diagnosis and treatment. Nephron 62:176 PubMedCrossRefGoogle Scholar
  74. 74.
    Weidner N, Santa CD (1987) Phosphaturic mesenchymal tumors. A polymorphous group causing osteomalacia or rickets. Cancer 59:1442–1454 PubMedCrossRefGoogle Scholar
  75. 75.
    Folpe AL, Fanburg-Smith JC, Weiss SW (2003) The Phosphaturic Mesenchymal Tumor Study Group. Most phosphaturic mesenchymal tumors are a single entity: an analysis of 31 cases. Mod Pathol 16:12A Google Scholar
  76. 76.
    Lyles KW, Berry WR, Haussler M et al (1980) Hypophosphatemic osteomalacia: association with prostatic carcinoma. Ann Intern Med 93:275–278 PubMedGoogle Scholar
  77. 77.
    Shaker JL, Brickner RC, Divgi AB et al (1995) Case report: renal phosphate wasting syndrome of inappropriate antidiuretic hormone, and ectopic corticotropin production in small cell carcinoma. Am J Med Sci 310:38–41 PubMedCrossRefGoogle Scholar
  78. 78.
    Saville PD, Nassim JR, Stevenson FH (1955) Osteomalacia in von Recklinghausen’s neurofibromatosis: Metabolic study of a case. Br Med J 1:1311–1313 PubMedCrossRefGoogle Scholar
  79. Naketano Donna Giacca Blue Dark Basic 79.
    Dent CE, Gertner JM (1976) Hypophosphataemic osteomalacia in fibrous dysplasia. Q J Med 45:411–420 PubMedGoogle Scholar
  80. 80.
    White KE, Jonsson KB, Cam G et al (2001) The Autosomal Dominant Hypophosphatemic Rickets (ADHR) gene is a secreted polypeptide overexpressed by tumours that cause phosphate wasting. J Clin Endocrin Metab 86:497–500 CrossRefGoogle Scholar
  81. 81.
    Jonsson KB, Zahradnik R, Larsson T et al (2003) Fibroblast growth factor 23 in oncogenic osteomalacia and Xlinked hypophosphatemia. N Engl J Med 348:1656–1663 PubMedCrossRefGoogle Scholar
  82. 82.
    Kumar R (2000) Tumor-induced osteomalacia and the regulation of phosphate homeostasis. Bone 27:333–338 PubMedCrossRefGoogle Scholar
  83. 83.
    Sebastian A, McSherry E, Morris RC Jr (1971) On the mechanism of renal potassium wasting in renal tubular acidosis associated with the Fanconi syndrome (type 2 RTA). J Clin Invest 50:231–243 PubMedCrossRefGoogle Scholar
  84. 84.
    Rodriguez Soriano J, Houston IB, Boichis H, Edelmann CM Jr (1968) Calcium and phosphorus metabolism in the Fanconi syndrome. J Clin Endocrinol Metab 28:1555–1563 CrossRefGoogle Scholar
  85. 85.
    Rodriquez Soriano J, Vallo A, Castillo G, Oliveros R (1980) Renal handling of water and sodium in children with proximal and distal renal tabular acidosis. Nephron 25:193–198 CrossRefGoogle Scholar
  86. 86.
    Houston IB, Boichis H, Edelmann CM Jr (1968) Fanconi syndrome with renal sodium wasting and metabolic alkalosis. Am J Med 44:638–646 PubMedCrossRefGoogle Scholar
  87. 87.
    Dillard MG, Pesce AJ, Pollak VE, Boreisha T (1971) Proteinuria and renal protein clearances in patients with renal tubular disorders. J Lab Clin Med 78:203–215 PubMedGoogle Scholar
  88. 88.
    Lee DB, Drinkard JP, Rosen VJ, Gonick HC (1972) The adult Fanconi syndrome: observations on etiology, morphology, renal function and mineral metabolism in three patients. Medicine (Baltimore) 51:107–138 CrossRefGoogle Scholar
  89. 89.
    Bushinsky DA, Frick KK (2000) The effects of acid on bone. Curr Opin Nephrol Hypertens 9:369–379 PubMedCrossRefGoogle Scholar
  90. 90.
    Eiamong S, Kurtzman NA (1994) Metabolic acidosis and bone disease. Miner Electrolyte Metab 20:72–80 Google Scholar
  91. 91.
  92. 92.
    Dalmak S, Erek E, Serdengecti K et al (1996) A case study of adult onset hypophosphatemic osteomalacia with idiopathic Fanconi syndrome. Nephron 72:121–122 PubMedCrossRefGoogle Scholar
  93. 93.
    Boyce BF, Smith L, Fogelman I et al (1984) Focal osteomalacia due to low-dose diphosphonate therapy in Paget’s disease. Lancet 1:821–824 PubMedCrossRefGoogle Scholar
  94. 94.
    Schenk RK, Olah AJ (1980) What is osteomalacia? Adv Exp Biol Med 128:549–562 Google Scholar
  95. 95.
    Russell RGG, Fleisch H (1975) Pyrophosphate and diphosphonate in skeletal metabolism. Physiological, clinical and therapeutic aspects. Clin Orthop 108:241–263 Blue Giacca Naketano Basic Dark Donna PubMedCrossRefGoogle Scholar
  96. 96.
    Khairi MRA, Altman RD, DeRosa GP. et al (1977) Sodium etidronate in the treatment of Paget’s disease of bone. A study of long-term results. Ann Intern Med 87:656–663 PubMedDark Blue Giacca Naketano Donna Basic Google Scholar
  97. 97.
  98. 98.
    Rossini M, Gatti D, Zamberlan N et al (1994) Long-term effects of a treatment course with oral alendronate of postmenopausal osteoporosis. J Bone Miner Res 9:1833–1837 PubMedCrossRefGoogle ScholarSportiva Giacca Woman Impermeabile Donna B Nero Antivento amp;c K Sirocco way Leggera vxq4Eww8
  99. 99.
    Briancon D, Meunier PJ (1981) Treatment of osteoporosis with fluoride, calcium, and vitamin D. Orthop Clin N Am 12:629–648 Google Scholar
  100. 100.
    Lundy MW, Stauffer M, Wergedal JE et al (1995) Histomorphometric analysis of iliac crest bone biopsies in placebo-treated versus fluoride-treated subjects. Osteoporos Int 5:115–129 PubMedCrossRefGoogle Scholar
  101. 101.
    Grennan DM, Palmer DG, Mathus RS et al (1978) Iatrogenic fluorosis. Aust NZ J Med 8:528–531 Donna Boot Blu Lee midtown Blues Jeans Skinny tHFFxqA
  102. 102.
    Compston JE, Chadha S, Merrett AL (1980) Osteomalacia developing during treatment of osteoporosis with sodium fluoride and vitamin D. Br Med J 281:910–911 PubMedCrossRefGoogle Scholar
  103. 103.
    Baker SL, Dent CE, Friedman N, Watson L (1966) Fibrogenesis imperfecta ossium. J Bone Joint Surg 48B:804–825 Google Scholar
  104. 104.
    Whyte MP (2001) Hypophosphatasia. In: Scriver CR, Beaudet AL, Sly WS et al (eds) The metabolic and molecular bases of inherited disease. McGraw-Hill, New York, pp 5313–5329 Google Scholar
  105. 105.
    Whyte MP, Vrabel LA, Schwartz TD (1983) Alkaline phosphatase deficiency in cultured skin fibroblasts from patients with hypophosphatasia: comparison of the infantile, childhood, and adult forms. J Clin Endocrinol Metab 57:831–837 PubMedCrossRefGoogle Scholar
  106. 106.
    Whyte MP, Walkenhorst DA, Fedde KN et al (1996) Hypophosphatasia: levels of bone alkaline phosphatase immunoreactivity in serum reflect disease severity. J Clin Endocrinol Metab 81:2142–2148 PubMedCrossRefGoogle Scholar
  107. 107.
    Caswell AM, Whyte MP, Russell RGG (1992) Hypophosphatasia and the extracellular metabolism of inorganic pyrophosphate: clinical and laboratory aspects. Crit Rev Clin Lab Sci 28:175–232 CrossRefGoogle Scholar
  108. 108.
    Whyte MP (2002) Hypophosphatasia: nature’s window on alkaline phosphatase function in man. In: Bilezikian J, Raisz L, Rodan G(eds) Principles of bone biology, 2nd ed. Academic Press, San Diego, pp 1229–1248 Google Scholar
  109. 109.
    Hessle L, Johnson KA, Anderson HC et al (2002) Tissuenonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci U S A 99:9445–9449 PubMedCrossRefGoogle Scholar
  110. 110.
    Weinstein RS, Whyte MP (1981) Heterogeneity of adult hypophosphatasia: report of severe and mild cases. Arch Intern Med 141:727–731 Donna Puluo Donna Puluo Giacca Giacca Brown fw1xnq4qdCrossRefGoogle Scholar
  111. 111.
    Whyte MP, Kurtzburg J, McAlister WH et al (2003) Marrow cell transplantation for infantile hypophosphatasia. J Bone Miner Res 18:624–636 PubMedCrossRefGoogle Scholar
  112. 112.
    Wenkert D, Podgornik MN, Coburn SP et al (2002) Dietary phosphate restriction therapy for hypophosphatasia: preliminary observations. J Bone Miner Res 17:S384 CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2009

Personalised recommendations

Rachitismo e osteomalacia
Buy options
Elefante Blu A Donna Da Zampa Vita Alta Di Con Pantaloni Casual xTvBwzY

We use cookies to personalise content and ads, to provide social media features and to analyse our traffic. We also share information about your use of our site with our social media, advertising and analytics partners in accordance with our Privacy Statement. You can manage your preferences in Manage Cookies.

Close
OK
Manage Cookies